Morbid obesity is a serious disease. Patients with morbid obesity are likely to develop a number of potentially serious health problems, including:
  - High triglycerides
  - Low high-density lipoprotein (HDL) cholesterol (the good cholesterol)
  - Type 2 diabetes mellitus
  - High blood pressure
  - Heart (cardiovascular) disease
  - Stroke
  - Breathing disorders, including snoring and sleep apnea
  - Gallbladder disease
  - Venous thromboembolic events (VTE)
  - For women: Gynecological problems, such as infertility and irregular periods
  - For men: Erectile dysfunction and sexual health issues
  - Cancer, including cancer of the uterus, cervix, endometrium, ovaries, breast, colon, rectum, esophagus, liver, gallbladder, pancreas, kidney and prostate
  - Nonalcoholic fatty liver disease (NAFLD) , a condition in which fat builds up in the liver and can cause inflammation or scarring. This condition leads to cirrhosis of the liver then liver failure.
  - Metabolic syndrome — a combination of high blood sugar, high blood pressure, high triglycerides and low HDL cholesterol
  - Osteoarthritis